For the quantitative measurement of Symmetric Dimethyl Arginine (SMDA) in serum.

Key Benefits:

Improve patient outcomes with early detection and monitoring of Chronic Kidney Disease (CKD)

Chronic kidney disease (CKD) is one of the most common diseases in aging dogs and cats, with very serious health consequences. Our kidney function test measures the serum concentration of Symmetric dimethyl arginine (SMDA). The International Renal Interest Society (IRIS) recognizes SDMA is a biomarker of renal function which can detect the disease months or even years earlier than traditional tests such as creatinine or BUN.1,2 Early detection and monitoring of this disease makes it possible for veterinarians to provide timely treatment and improve their patient’s quality of life.

  • Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  • Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.

Sample Requirements:

Sample Type Sample Volume Sample Collection Method
Serum  0.5 mL Dried Spot (DS) Cards


Methodology: LCMS

Interpretation of Results:

Stages of CKD Canine Feline
1 <1.4 µg/dL <1.6 µg/dL
2 1.4-2.0 µg/dL 1.6-2.8 µg/dL
3 2.1-5.0 µg/dL 2.9-5.0 µg/dL
4 >5.0 µg/dL >5.0 µg/dL